
For patients with severe functional mitral regurgitation and symptomatic heart failure (left ventricular ejection fraction between 20-50%) despite best medical therapy.
The COAPT Risk Score1 is a simple risk prediction tool created by combining clinical and echocardiographic variables in patients with heart failure (HF) and moderate-to-severe or severe functional mitral regurgitation (FMR) who remain symptomatic despite maximally tolerated guideline directed medical therapy (GDMT). The COAPT Risk Score provides valuable prognostic information regarding the 2-year risk of death and/or heart failure hospitalization (HFH). The score is derived from the COAPT trial2 population of patients with HF and moderate-to-severe or severe FMR randomized to treatment with either transcatheter edge-to-edge repair (TEER) with MitraClip plus GDMT or GDMT alone. We can incorporate TEER in the risk score and provide updated 2-year risk of death and/or HFH which can serve as a valuable shared decision-making tool for patients and physicians as well as heart teams while deciding about TEER.
The COAPT Risk Score has been externally validated in several registries3-5 showing fair predictive accuracy. Additionally, continued follow-up of COAPT trial patients showed that TEER was safe and effective with lower rate of death and HFH (compared to GDMT alone) at 3 years6 and 5 years.7
For full-text link to the COAPT risk score paper, please click here.
Team

Annapoorna Kini
MD, MRCP, FACC, FSCAI
Director, Cardiac Catheterization Laboratory
System Director, Structural Heart Disease Program
Director, Interventional Cardiology Fellowship Program
Zena and Michael A. Wiener Professor of Medicine
Icahn School of Medicine at Mount Sinai

Samin Sharma
MD, FACC, MSCAI
Director, Clinical and Interventional Cardiology
President, Mount Sinai Heart Network
Dean, International Clinical Affiliations
Anandi Lal Sharma Professor of Medicine
Icahn School of Medicine at Mount Sinai

Gilbert H.L. Tang
MD, MSc, MBA, FRCSC, FACC, FSCAI
Surgical Director, Structural Heart Program
Professor, Cardiovascular Surgery
The Mount Sinai Health System

Gregg Stone
MD, FACC, FSCAI
Professor, Cardiology
Professor, Population Health Science and Policy
Icahn School of Medicine at Mount Sinai

Neeraj N. Shah
MD
Assistant Professor, Cardiology
ECU Health Medical Center

Sahil Khera
MD, MPH, FACP, FACC, FSCAI
Interventional Director, Structural Heart Disease Program
Assistant Professor, Cardiology
The Mount Sinai Hospital
The development of this app was made possible by the generous support of
